A: Yes, absolutely. The Ubiquiti UC-Cast is designed to work with any HDMI-compatible display, which includes the NEC V461. The two devices are a common and effective pairing for creating a professional digital signage network.
Ensure the following transport layer ports are explicitly open within your security router configuration: : 5000–5050 (Media Streaming) ucast v461 fix
If the audio still drifts, look at the section in OBS. A: Yes, absolutely