Interrupting an opponent's signature animation right as they telegraph an attack rewards you with a Star. You can bank up to three stars. Press the Start Button (Enter) to unleash a high-damage uppercut, but be careful—getting hit will cause you to lose all banked stars instantly.
For those who may be unfamiliar, Mike Tyson's Punch-Out! is a side-scrolling boxing game that follows the journey of Little Mac, a young boxer from Brooklyn, as he rises through the ranks to face off against the game's titular champion, Mike Tyson. The game is known for its simple yet engaging gameplay, which involves timing punches and dodging opponents' attacks to emerge victorious.
A fan-favourite puzzle fight. Wait for him to open his mouth to punch. Hit him in the face to make his pants drop, then repeatedly strike his exposed bandage on his stomach until he falls.
: Features a large library of NES titles including the original Mike Tyson edition. Internet Archive
Practical tips for playing (safely and effectively)